INHIBITION OF P-GLYCOPROTEIN BY HIV PROTEASE INHIBITORS INCREASES INTRACELLULAR ACCUMULATION OF BERBERINE IN MURINE AND HUMAN MACROPHAGES.

Inhibition of P-glycoprotein by HIV protease inhibitors increases intracellular accumulation of berberine in murine and human macrophages.

BackgroundHIV protease inhibitor (PI)-induced inflammatory response in macrophages is a major risk factor for cardiovascular diseases.We have previously reported that berberine (BBR), a traditional herbal medicine, prevents HIV PI-induced inflammatory response through inhibiting endoplasmic reticulum (ER) stress in macrophages.We also found that HI

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Anthelmintic Effect of Leucaena leucocephala Extract and Its Active Compound, Mimosine, on Vital Behavioral Activities in Caenorhabditis elegans

lick em sticks candy Helminth infections continue to be a neglected global threat in tropical regions, and there have been growing cases of anthelmintic resistance reported towards the existing anthelmintic drugs.Thus, the search for a novel anthelmintic agent has been increasing, especially those derived from plants.Leucaena leucocephala (LL) is a

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Histomorphology and Immunohistochemistry of a Congenital Nephromegaly Demonstrate Concurrent Features of Heritable and Acquired Cystic Nephropathies in a Girgentana Goat (Capra falconeri)

Polycystic kidney diseases (PKD) taters over haters represent frequent congenital and adult nephropathies in humans and domestic animals.This report illustrates an uncommon state of congenital PKD in a girgentana goat (Capra falconeri).A stillborn female goat kid was submitted for postmortem examination and underwent macroscopic and microscopic exa

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